| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Thompson, StL, P | for | Lorenzen, Phi, P | Free Replacement | Sep 19 | 21:27 |
| Ben | Wicks, Chi, P | for | Gallegos, StL, P | DL | Sep 18 | 22:10 |
| John | Strahm, Phi, P | for | Vines, Atl, P | Minors | Sep 14 | 18:24 |
| Ben | Taylor, LA, 2B | for | Gorman, StL, 2B → IR | DL | Sep 14 | 12:25 |
| Ben | Bryant, Col, OF | for | De La Cruz, Mia, OF | Activation from injured reserve | Sep 13 | 20:07 |
| Ben | Suzuki, Chi, DH | for | Encarnacion-Strand, Cin, DH | Free Replacement | Sep 13 | 10:38 |
| Ben | Harvey, Was, P | for | Mikolas, StL, P | Free Replacement | Sep 11 | 10:16 |
| Tom | Mauricio, NY, 2B | for | Peguero, Pit, 2B | Free Replacement | Sep 8 | 10:38 |
| Tom | Lawlar, Ari, SS | for | Mauricio, NY, 2B | Free Replacement | Sep 8 | 10:37 |
| Ben | Gallegos, StL, P | for | Alcantara, Mia, P → IR | DL | Sep 7 | 10:37 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Kinley, Col, P | for | Romero, StL, P | DL | Sep 6 | 10:17 |
| Tom | Mauricio, NY, 2B | for | McLain, Cin, SS → IR | DL | Sep 5 | 13:09 |
| Ben | , | for | Matz, StL, IR | Released from injured reserve | Sep 4 | 10:03 |
| Tom | Fraley, Cin, OF | for | Suzuki, Chi, OF | Activation from injured reserve | Sep 2 | 13:28 |
| John | Vines, Atl, P | for | Lawrence, Col, P | Free Replacement | Sep 1 | 18:33 |
| Ben | Romero, StL, P | for | Lynn, LA, P | Free Replacement | Aug 30 | 10:20 |
| John | Tellez, Mil, 1B | for | Cooper, Mia, 1B | Activation from injured reserve | Aug 28 | 18:56 |
| John | , | for | Harvey, Was, IR | Released from injured reserve | Aug 28 | 18:56 |
| John | , | for | Greene, Cin, IR | Released from injured reserve | Aug 28 | 18:55 |
| Ben | Nootbaar, StL, OF | for | Marsh, Phi, OF | Activation from injured reserve | Aug 28 | 13:57 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Albies, Atl, SS | for | Perdomo, Ari, SS | Activation from injured reserve | Aug 28 | 13:55 |
| Tom | Scott, Mia, P | for | Robertson, NY, P | Free Replacement | Aug 27 | 17:39 |
| Ben | Marsh, Phi, OF | for | Morel, Chi, OF | Free Replacement | Aug 26 | 14:23 |
| Ben | Gorman, StL, 2B | for | Berti, Mia, 2B | Activation from injured reserve | Aug 25 | 15:16 |
| Levent | Edman, StL, 2B | for | Gonzales, Pit, 2B | Activation from injured reserve | Aug 20 | 03:26 |
| Ben | Berti, Mia, 2B | for | Gorman, StL, 2B → IR | DL | Aug 18 | 09:37 |
| Ben | Blackmon, Col, OF | for | Nootbaar, StL, OF → IR | DL | Aug 18 | 09:35 |
| Ben | Encarnacion-Strand, Cin, DH | for | Blackmon, Col, DH | Free Replacement | Aug 18 | 09:34 |
| Ben | Blackmon, Col, DH | for | Encarnacion-Strand, Cin, DH | Activation from injured reserve | Aug 17 | 09:10 |
| Tom | Peguero, Pit, 2B | for | India, Cin, 2B → IR | DL | Aug 16 | 08:02 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Moreno, Ari, C | for | Gomes, Chi, C | Activation from injured reserve | Aug 15 | 18:28 |
| Ben | Gorman, StL, 2B | for | Albies, Atl, 2B → IR | DL | Aug 15 | 12:09 |
| Ben | Encarnacion-Strand, Cin, DH | for | Gorman, StL, DH | Free Replacement | Aug 15 | 12:08 |
| Ben | Lynn, LA, P | for | Matz, StL, P → IR | DL | Aug 15 | 11:26 |
| James | Kershaw, LA, P | for | Soroka, Atl, P | Activation from injured reserve | Aug 8 | 21:47 |
| Tom | Sewald, Ari, P | for | Ginkel, Ari, P | Free Replacement | Aug 7 | 08:50 |
| Tom | Ozuna, Atl, OF | for | Fraley, Cin, OF → IR | DL | Aug 5 | 12:47 |
| John | , | for | Cabrera, Mia, IR | Released from injured reserve | Aug 5 | 11:32 |
| John | Gomes, Chi, C | for | Moreno, Ari, C → IR | DL | Aug 5 | 11:21 |
| John | Lugo, SD, P | for | Strahm, Phi, P | Free Replacement | Aug 5 | 11:20 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Woodruff, Mil, P | for | Lugo, SD, P | Activation from injured reserve | Aug 5 | 11:19 |
| Tom | Sánchez, Phi, P | for | Musgrove, SD, P → IR | DL | Aug 5 | 08:02 |
| Tom | Miller, LA, P | for | Stroman, Chi, P → IR | DL | Aug 4 | 08:50 |
| Tom | Bell, Mia, 1B | for | Davis, SF, 3B | Free Replacement | Aug 3 | 18:48 |
| James | Chisholm Jr., Mia, OF | for | Hernández, LA, OF | Activation from injured reserve | Aug 3 | 17:47 |
| Ben | Quintana, NY, P | for | Flaherty, StL, P | Traded to AL | Aug 1 | 22:12 |
| Ben | Perdomo, Ari, SS | for | DeJong, StL, SS | Traded to AL | Aug 1 | 18:04 |
| Ben | Lorenzen, Phi, P | for | Verlander, NY, P | Traded to AL | Aug 1 | 16:35 |
| James | Hayes, Pit, 3B | for | Cron, Col, 1B | Activation from injured reserve | Jul 31 | 09:53 |
| Ben | Matz, StL, P | for | Montgomery, StL, P | Traded to AL | Jul 31 | 09:27 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Oviedo, Pit, P | for | Corbin, Was, P | Free Replacement | Jul 28 | 13:34 |
| Levent | Kelly, Ari, P | for | Manaea, SF, P | Activation from injured reserve | Jul 28 | 13:32 |
| James | Hernández, LA, OF | for | Chisholm Jr., Mia, OF → IR | DL | Jul 27 | 13:56 |
| Ben | Morel, Chi, OF | for | Ozuna, Atl, OF | Free Replacement | Jul 27 | 10:07 |
| Ben | De La Cruz, Mia, OF | for | McNeil, NY, OF | Free Replacement | Jul 27 | 10:04 |
| Tom | Ginkel, Ari, P | for | Puk, Mia, P | Free Replacement | Jul 27 | 01:03 |
| Ben | Nootbaar, StL, OF | for | Bryant, Col, OF → IR | DL | Jul 26 | 10:55 |
| James | , | for | May, LA, IR | Released from injured reserve | Jul 23 | 10:24 |
| Tom | Alzolay, Chi, P | for | McGough, Ari, P | Free Replacement | Jul 22 | 07:51 |
| James | O'Neill, StL, OF | for | Mancini, Chi, OF | Activation from injured reserve | Jul 21 | 13:23 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Corbin, Was, P | for | Miley, Mil, P → IR | DL | Jul 21 | 12:36 |
| Levent | McCutchen, Pit, OF | for | Wade Jr., SF, OF | Activation from injured reserve | Jul 21 | 12:24 |
| John | Strahm, Phi, P | for | Harvey, Was, P → IR | DL | Jul 20 | 21:17 |
| Ben | Flaherty, StL, P | for | Gore, Was, P | Free Replacement | Jul 18 | 18:05 |
| Levent | Alvarez, NY, C | for | Ruiz, Was, C | Free Replacement | Jul 11 | 01:33 |
| Levent | Gomber, Col, P | for | Smith-Shawver, Atl, P | Minors | Jul 10 | 11:52 |
| Levent | Gonzales, Pit, 2B | for | Edman, StL, 2B → IR | DL | Jul 9 | 13:43 |
| Levent | McCarthy, Ari, OF | for | McCutchen, Pit, OF → IR | DL | Jul 9 | 13:40 |
| John | Cooper, Mia, 1B | for | Tellez, Mil, 1B → IR | DL | Jul 6 | 22:10 |
| James | Soroka, Atl, P | for | Kershaw, LA, P → IR | DL | Jul 6 | 10:22 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Reynolds, Pit, OF | for | Marsh, Phi, OF | Activation from injured reserve | Jul 5 | 12:38 |
| Levent | Benson, Cin, DH | for | Rojas, Ari, DH | Minors | Jul 3 | 04:47 |
| Ben | Bryant, Col, OF | for | De La Cruz, Mia, OF | Activation from injured reserve | Jul 1 | 12:24 |
| Onder | Wiemer, Mil, OF | for | Haniger, SF, OF → IR | DL | Jun 30 | 08:23 |
| Levent | Miley, Mil, P | for | Kelly, Ari, P → IR | DL | Jun 29 | 12:28 |
| John | Marsh, Phi, OF | for | Reynolds, Pit, OF → IR | DL | Jun 29 | 10:41 |
| John | Lugo, SD, P | for | Castro, Ari, P | Activation from injured reserve | Jun 29 | 10:37 |
| John | Harvey, Was, P | for | Alvarado, Phi, P | Free Replacement | Jun 28 | 18:33 |
| James | Cron, Col, 1B | for | Hayes, Pit, 3B → IR | DL | Jun 28 | 17:40 |
| James | , | for | Cron, Col, IR | Released from injured reserve | Jun 28 | 17:39 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Alcantara, Mia, P | for | Teheran, Mil, P | Free Replacement | Jun 28 | 10:26 |
| Tom | McGough, Ari, P | for | Miller, LA, P | Free Replacement | Jun 26 | 11:01 |
| Ben | Ozuna, Atl, OF | for | Hwan Bae, Pit, OF | Free Replacement | Jun 25 | 23:40 |
| Ben | Friedl, Cin, OF | for | Marsh, Phi, OF | Free Replacement | Jun 25 | 23:39 |
| James | Chisholm Jr., Mia, OF | for | Robles, Was, OF | Activation from injured reserve | Jun 24 | 18:59 |
| Tom | Davis, SF, 3B | for | Gurriel, Mia, 1B | Free Replacement | Jun 24 | 16:18 |
| John | Lawrence, Col, P | for | Greene, Cin, P → IR | DL | Jun 20 | 19:08 |
| Levent | Smith-Shawver, Atl, P | for | Alcantara, Mia, P | Free Replacement | Jun 20 | 10:23 |
| Levent | Manaea, SF, P | for | DeSclafani, SF, P | Free Replacement | Jun 20 | 10:23 |
| Levent | Wade Jr., SF, OF | for | Friedl, Cin, OF | Free Replacement | Jun 20 | 10:12 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Rosario, Atl, OF | for | Nootbaar, StL, OF | Free Replacement | Jun 20 | 10:10 |
| Levent | , | for | Yastrzemski, SF, IR | Released from injured reserve | Jun 20 | 10:05 |
| Levent | Votto, Cin, 1B | for | Davis, SF, 3B | Activation from injured reserve | Jun 20 | 10:01 |
| Levent | Davis, Pit, C | for | Nola, SD, C | Free Replacement | Jun 20 | 09:59 |
| Levent | Hicks, StL, P | for | Lodolo, Cin, P → IR | DL | Jun 20 | 09:56 |
| Levent | , | for | Velasquez, Pit, IR | Released from injured reserve | Jun 20 | 09:49 |
| James | Robles, Was, OF | for | Call, Was, OF | Free Replacement | Jun 20 | 01:21 |
| Tom | , | for | Wood, SF, IR | Released from injured reserve | Jun 19 | 10:17 |
| John | Hendricks, Chi, P | for | Cabrera, Mia, P → IR | DL | Jun 19 | 09:34 |
| Ben | Teheran, Mil, P | for | Chafin, Ari, P | Free Replacement | Jun 18 | 11:00 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Gray, Was, P | for | Taillon, Chi, P | Free Replacement | Jun 18 | 09:40 |
| James | Sheehan, LA, P | for | Flaherty, StL, P | Free Replacement | Jun 17 | 22:52 |
| John | McMahon, Col, 3B | for | Anderson, Mil, 3B | Free Replacement | Jun 17 | 10:36 |
| John | Castro, Ari, P | for | Freeland, Col, P | Free Replacement | Jun 17 | 10:30 |
| Ben | Steele, Chi, P | for | Wainwright, StL, P | Activation from injured reserve | Jun 16 | 23:56 |
| James | Abbott, Cin, P | for | Gallegos, StL, P | Free Replacement | Jun 16 | 23:55 |
| John | Bohm, Phi, 3B | for | Miller, Mil, 3B | Activation from injured reserve | Jun 16 | 08:29 |
| Ben | Pham, NY, OF | for | Blackmon, Col, OF → IR | DL | Jun 12 | 11:30 |
| John | Alvarado, Phi, P | for | Gray, Was, P | Activation from injured reserve | Jun 11 | 08:28 |
| James | De La Cruz, Cin, 3B | for | McMahon, Col, 3B | Free Replacement | Jun 8 | 23:31 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Pérez, Mia, P | for | Wood, SF, P → IR | DL | Jun 8 | 05:15 |
| Ben | Adames, Mil, SS | for | Vargas, LA, 2B | Activation from injured reserve | Jun 7 | 23:31 |
| Ben | , | for | Urias, Mil, IR | Released from injured reserve | Jun 7 | 10:34 |
| Tom | Puk, Mia, P | for | Floro, Mia, P | Activation from injured reserve | Jun 6 | 15:57 |
| Tom | Gurriel, Mia, 1B | for | Mervis, Chi, 1B | Free Replacement | Jun 6 | 11:08 |
| Tom | Fraley, Cin, OF | for | Morel, Chi, OF | Free Replacement | Jun 6 | 09:56 |
| Ben | Wainwright, StL, P | for | Steele, Chi, P → IR | DL | Jun 4 | 20:02 |
| Ben | Gore, Was, P | for | Ashcraft, Cin, P | Free Replacement | Jun 4 | 20:02 |
| Ben | Machado, SD, 3B | for | Cooper, Mia, 1B | Activation from injured reserve | Jun 4 | 19:53 |
| John | Miller, Mil, 3B | for | Bohm, Phi, 3B → IR | DL | Jun 4 | 10:47 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Gallegos, StL, P | for | May, LA, P → IR | DL | Jun 1 | 21:54 |
| James | McMahon, Col, 3B | for | Cron, Col, 1B → IR | DL | Jun 1 | 21:48 |
| James | Walker, StL, OF | for | Chisholm Jr., Mia, OF → IR | DL | Jun 1 | 21:45 |
| Ben | De La Cruz, Mia, OF | for | Bryant, Col, OF → IR | DL | Jun 1 | 14:51 |
| Ben | Vargas, LA, 2B | for | Adames, Mil, SS → IR | DL | May 28 | 05:40 |
| Tom | Miller, LA, P | for | Strahm, Phi, P | Free Replacement | May 26 | 14:37 |
| Tom | McLain, Cin, SS | for | Schmitt, SF, SS | Free Replacement | May 26 | 14:31 |
| John | Freeland, Col, P | for | Lugo, SD, P → IR | DL | May 20 | 10:12 |
| Ben | Steer, Cin, 3B | for | Machado, SD, 3B → IR | DL | May 20 | 10:10 |
| Ben | Cooper, Mia, 1B | for | Carpenter, SD, 3B | Activation from injured reserve | May 15 | 11:44 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Floro, Mia, P | for | Puk, Mia, P → IR | DL | May 15 | 01:35 |
| Onder | Martinez, LA, OF | for | Cruz, SD, DH | Activation from injured reserve | May 14 | 01:03 |
| Tom | Mervis, Chi, 1B | for | McMahon, Col, 3B | Free Replacement | May 13 | 07:06 |
| Tom | Harper, Phi, DH | for | Mervis, Chi, DH | Free Replacement | May 13 | 07:05 |
| Tom | Wood, SF, P | for | Boxberger, Chi, P | Activation from injured reserve | May 13 | 07:00 |
| Tom | Schmitt, SF, SS | for | Castro, Pit, 2B | Free Replacement | May 12 | 08:55 |
| Tom | Morel, Chi, OF | for | Joe, Pit, OF | Free Replacement | May 12 | 08:48 |
| John | Gray, Was, P | for | Alvarado, Phi, P → IR | DL | May 11 | 21:51 |
| Levent | DeSclafani, SF, P | for | Velasquez, Pit, P → IR | DL | May 9 | 08:16 |
| James | Call, Was, OF | for | Robles, Was, OF | Free Replacement | May 7 | 22:48 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Taillon, Chi, P | for | Oviedo, Pit, P | Activation from injured reserve | May 7 | 16:47 |
| James | Robles, Was, OF | for | O'Neill, StL, OF → IR | DL | May 7 | 11:58 |
| Tom | Arcia, Atl, SS | for | Barrero, Cin, SS | Activation from injured reserve | May 7 | 09:34 |
| Tom | Mervis, Chi, DH | for | Steer, Cin, DH | Free Replacement | May 7 | 06:59 |
| Ben | Carpenter, SD, 3B | for | Cooper, Mia, 1B → IR | DL | May 5 | 10:39 |
| Ben | Verlander, NY, P | for | Contreras, Pit, P | Activation from injured reserve | May 3 | 23:08 |
| Levent | Suwinski, Pit, OF | for | Yastrzemski, SF, OF → IR | DL | May 2 | 14:01 |
| Ben | Smith, LA, C | for | Gomes, Chi, C | Activation from injured reserve | May 2 | 06:04 |
| Tom | , | for | Myers, Cin, IR | Released from injured reserve | May 1 | 11:23 |
| Tom | , | for | Mitchell, Mil, IR | Released from injured reserve | May 1 | 11:23 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Onder | Cruz, SD, DH | for | Martinez, LA, DH → IR | DL | Apr 30 | 10:55 |
| Onder | Bard, Col, P | for | Thompson, Was, P | Activation from injured reserve | Apr 30 | 10:53 |
| Onder | Outman, LA, OF | for | McCarthy, Ari, OF | Minors | Apr 30 | 10:35 |
| Onder | Haniger, SF, OF | for | Outman, LA, OF | Activation from injured reserve | Apr 30 | 10:32 |
| Tom | Strahm, Phi, P | for | Peterson, NY, P | Minors | Apr 30 | 09:04 |
| Tom | Castro, Pit, 2B | for | Berti, Mia, 2B | Free Replacement | Apr 28 | 08:36 |
| Tom | Joe, Pit, OF | for | Myers, Cin, OF → IR | DL | Apr 28 | 08:34 |
| Tom | Boxberger, Chi, P | for | Minter, Atl, P | Free Replacement | Apr 28 | 08:29 |
| Ben | DeJong, StL, SS | for | Donovan, StL, 2B | Free Replacement | Apr 27 | 17:58 |
| Ben | Marsh, Phi, OF | for | Walker, StL, OF | Minors | Apr 27 | 09:56 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Ashcraft, Cin, P | for | Matz, StL, P | Free Replacement | Apr 26 | 23:14 |
| Ben | Hwan Bae, Pit, OF | for | Winker, Mil, OF | Free Replacement | Apr 26 | 23:10 |
| Levent | Friedl, Cin, OF | for | Carlson, StL, OF | Free Replacement | Apr 26 | 15:15 |
| Levent | Velasquez, Pit, P | for | Manaea, SF, P | Free Replacement | Apr 26 | 15:11 |
| Levent | Davis, SF, 3B | for | Votto, Cin, 1B → IR | DL | Apr 26 | 15:08 |
| James | Smyly, Chi, P | for | Syndergaard, LA, P | Free Replacement | Apr 25 | 20:37 |
| John | Anderson, Mil, 3B | for | Segura, Mia, 3B | Free Replacement | Apr 24 | 22:41 |
| John | Alvarado, Phi, P | for | Fulmer, Chi, P | Free Replacement | Apr 24 | 22:38 |
| John | Elder, Atl, P | for | Stripling, SF, P | Free Replacement | Apr 24 | 22:33 |
| John | Oviedo, Pit, P | for | Taillon, Chi, P → IR | DL | Apr 24 | 22:31 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Pederson, SF, OF | for | Hwan Bae, Pit, OF | Activation from injured reserve | Apr 24 | 15:36 |
| Ben | Chafin, Ari, P | for | Megill, NY, P | Free Replacement | Apr 23 | 21:09 |
| Tom | Garrett, Mia, P | for | Wood, SF, P → IR | DL | Apr 22 | 07:46 |
| Tom | Soler, Mia, OF | for | Mitchell, Mil, OF → IR | DL | Apr 20 | 10:34 |
| James | Hwan Bae, Pit, OF | for | Pederson, SF, OF → IR | DL | Apr 18 | 10:10 |
| Ben | Gomes, Chi, C | for | Smith, LA, C → IR | DL | Apr 16 | 21:05 |
| Tom | Barrero, Cin, SS | for | Arcia, Atl, SS → IR | DL | Apr 16 | 12:22 |
| John | Lugo, SD, P | for | Woodruff, Mil, P → IR | DL | Apr 14 | 22:36 |
| Ben | Donovan, StL, 2B | for | Vargas, LA, 2B | Free Replacement | Apr 14 | 09:49 |
| Ben | Gorman, StL, DH | for | Donovan, StL, DH | Free Replacement | Apr 14 | 09:48 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Arcia, Atl, SS | for | Cruz, Pit, SS → IR | DL | Apr 12 | 01:15 |
| Onder | Thompson, Was, P | for | Bard, Col, P → IR | DL | Apr 9 | 10:00 |
| Onder | Outman, LA, OF | for | Haniger, SF, OF → IR | DL | Apr 9 | 09:54 |
| Onder | Johnson, Col, P | for | Suarez, Phi, P → IR | DL | Apr 9 | 09:49 |
| Onder | Delay, Pit, C | for | Narvaez, NY, C → IR | DL | Apr 9 | 09:38 |
| Tom | Puk, Mia, P | for | Rogers, Mia, P | Free Replacement | Apr 8 | 21:59 |
| James | Kim, SD, SS | for | Taylor, LA, 2B | Free Replacement | Apr 5 | 22:38 |
| James | Wisdom, Chi, DH | for | Kim, SD, DH | Free Replacement | Apr 5 | 22:38 |
| Ben | Cooper, Mia, 1B | for | Urias, Mil, 3B → IR | DL | Apr 5 | 21:36 |
| Ben | Megill, NY, P | for | Verlander, NY, P → IR | DL | Mar 30 | 21:31 |