| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | , | for | Weathers, Mia, IR | Released from injured reserve | Sep 22 | 21:40 |
| John | Williams, Was, P | for | Peterson, NY, P | Activation from injured reserve | Sep 22 | 21:40 |
| Ben | Steele, Chi, P | for | Herz, Was, P | Activation from injured reserve | Sep 18 | 10:00 |
| Ben | Herz, Was, P | for | Steele, Chi, P → IR | DL | Sep 17 | 09:57 |
| Ben | , | for | Glasnow, LA, IR | Released from injured reserve | Sep 17 | 09:54 |
| Ben | , | for | Contreras, StL, IR | Released from injured reserve | Sep 17 | 09:54 |
| Ben | Grandal, Pit, C | for | d'Arnaud, Atl, C | Free Replacement | Sep 9 | 10:28 |
| Tom | Bart, SF, C | for | Del Castillo, Ari, C | Activation from injured reserve | Sep 8 | 07:19 |
| James | Buehler, LA, P | for | Miller, LA, P | Free Replacement | Sep 5 | 14:30 |
| Ben | Edwards, Mia, SS | for | Perdomo, Ari, SS | Activation from injured reserve | Sep 4 | 23:18 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Darvish, SD, P | for | Blackburn, NY, P | Activation from injured reserve | Sep 3 | 17:45 |
| Tom | Tatis Jr., SD, OF | for | Soler, SF, OF | Activation from injured reserve | Sep 3 | 03:50 |
| Tom | Fraley, Cin, OF | for | Crews, Was, OF | Activation from injured reserve | Sep 2 | 08:52 |
| Ben | Crow-Armstrong, Chi, OF | for | Edman, StL, OF | Free Replacement | Aug 28 | 17:54 |
| James | Miller, LA, P | for | Phillips, LA, P | Free Replacement | Aug 27 | 19:49 |
| James | Blalock, Mil, P | for | Greene, Cin, P → IR | DL | Aug 27 | 19:44 |
| Tom | Crews, Was, OF | for | Fraley, Cin, OF → IR | DL | Aug 27 | 13:06 |
| Tom | Jones, Pit, P | for | Ray, SF, P | Activation from injured reserve | Aug 27 | 11:25 |
| Ben | Perdomo, Ari, SS | for | Edwards, Mia, SS → IR | DL | Aug 27 | 10:28 |
| Tom | Herrera, StL, C | for | Bart, SF, C → IR | DL | Aug 26 | 12:36 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Peterson, NY, P | for | Falter, Pit, P | Free Replacement | Aug 25 | 18:10 |
| John | Assad, Chi, P | for | Sewald, Ari, P | Free Replacement | Aug 25 | 18:05 |
| John | Severino, NY, P | for | Waldron, SD, P → IR | Minors | Aug 25 | 15:47 |
| John | Donovan, StL, 2B | for | Kim, SD, 2B → IR | DL | Aug 25 | 15:44 |
| John | Sanchez, Mil, C | for | Diaz, Col, C | Free Replacement | Aug 25 | 15:36 |
| Ben | d'Arnaud, Atl, C | for | Contreras, StL, C → IR | DL | Aug 25 | 14:26 |
| James | Fried, Atl, P | for | Buehler, LA, P | Activation from injured reserve | Aug 22 | 13:47 |
| Tom | Suarez, Phi, P | for | Birdsong, SF, P | Activation from injured reserve | Aug 22 | 05:52 |
| Tom | Martínez, Ari, P | for | Severino, NY, P | Free Replacement | Aug 22 | 05:51 |
| Ben | Edman, StL, OF | for | Bader, NY, OF | Activation from injured reserve | Aug 21 | 08:16 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Blackburn, NY, P | for | Neris, Chi, P | Free Replacement | Aug 20 | 14:18 |
| Ben | Walker, SF, P | for | Megill, Mil, P | DL | Aug 20 | 12:53 |
| Ben | Muncy, LA, 3B | for | Hoskins, Mil, 1B | Activation from injured reserve | Aug 20 | 12:34 |
| Tom | Del Castillo, Ari, C | for | d'Arnaud, Atl, C | Free Replacement | Aug 20 | 07:27 |
| Tom | France, Cin, 1B | for | Candelario, Cin, 3B | Free Replacement | Aug 20 | 07:26 |
| Tom | Bart, SF, C | for | Bailey, SF, C | Free Replacement | Aug 19 | 19:43 |
| Ben | Irvin, Was, P | for | Glasnow, LA, P → IR | DL | Aug 17 | 08:59 |
| Ben | Edwards, Mia, SS | for | Gorman, StL, 2B | Free Replacement | Aug 15 | 14:26 |
| Tom | , | for | Brown, Chi, IR | Released from injured reserve | Aug 15 | 10:00 |
| Tom | Harris II, Atl, OF | for | Pham, NY, OF | Activation from injured reserve | Aug 15 | 09:59 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | McCarthy, Ari, OF | for | Marsh, Phi, OF | Free Replacement | Aug 13 | 10:45 |
| Ben | Sanchez, Mia, OF | for | Nootbaar, StL, OF | Free Replacement | Aug 13 | 10:39 |
| James | Buehler, LA, P | for | Miller, LA, P | Activation from injured reserve | Aug 12 | 18:17 |
| Tom | Musgrove, SD, P | for | Ryan, LA, P | Activation from injured reserve | Aug 11 | 23:21 |
| Tom | Estévez, Phi, P | for | Hudson, LA, P | Free Replacement | Aug 11 | 10:13 |
| John | , | for | Luzardo, Mia, IR | Released from injured reserve | Aug 9 | 22:58 |
| John | , | for | Winn, SF, IR | Released from injured reserve | Aug 9 | 22:58 |
| John | Wood, Was, OF | for | Frelick, Mil, OF | Free Replacement | Aug 9 | 22:57 |
| John | Betts, LA, OF | for | Wood, Was, OF | Activation from injured reserve | Aug 9 | 22:57 |
| Ben | , | for | Rojas, LA, IR | Released from injured reserve | Aug 8 | 10:41 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Fedde, StL, P | for | Irvin, Was, P | Free Replacement | Aug 7 | 23:09 |
| John | Higashioka, SD, C | for | Murphy, Atl, C | Free Replacement | Aug 7 | 19:36 |
| Ben | Pederson, Ari, DH | for | Donovan, StL, DH | Free Replacement | Aug 7 | 15:35 |
| Ben | Flaherty, LA, P | for | Gore, Was, P | Free Replacement | Aug 7 | 10:59 |
| Ben | Fitzgerald, SF, SS | for | Sosa, Phi, SS | Free Replacement | Aug 6 | 08:44 |
| Tom | Birdsong, SF, P | for | Suarez, Phi, P → IR | DL | Aug 5 | 12:49 |
| John | Falter, Pit, P | for | Quintana, NY, P | Activation from injured reserve | Aug 3 | 20:50 |
| John | Quintana, NY, P | for | Knack, LA, P | Minors | Aug 3 | 20:45 |
| Tom | Ryan, LA, P | for | Ortiz, Pit, P | Free Replacement | Aug 3 | 06:20 |
| John | Ramos, SF, OF | for | Thomas, Was, OF | Traded to AL | Aug 2 | 18:47 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Pham, NY, OF | for | Ramos, SF, OF | Free Replacement | Aug 1 | 07:42 |
| Tom | Bellinger, Chi, OF | for | Chisholm Jr., Mia, OF | Activation from injured reserve | Jul 31 | 21:28 |
| Ben | Schwellenbach, Atl, P | for | Senga, NY, P → IR | DL | Jul 28 | 11:40 |
| Tom | Friedl, Cin, OF | for | Sanchez, Mia, OF | Activation from injured reserve | Jul 27 | 13:53 |
| Tom | Ray, SF, P | for | Scott, NY, P | Free Replacement | Jul 25 | 16:00 |
| Ben | Sosa, Phi, SS | for | Rojas, LA, SS → IR | DL | Jul 25 | 15:25 |
| Tom | Hudson, LA, P | for | Chapman, Pit, P | Free Replacement | Jul 24 | 11:18 |
| John | , | for | Assad, Chi, IR | Released from injured reserve | Jul 23 | 18:57 |
| James | Kershaw, LA, P | for | Fried, Atl, P → IR | DL | Jul 22 | 12:14 |
| Ben | Senga, NY, P | for | Mikolas, StL, P | Activation from injured reserve | Jul 15 | 12:19 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Stallings, Col, C | for | Sanchez, Mil, C | Free Replacement | Jul 12 | 16:25 |
| James | Alvarez, NY, C | for | Amaya, Chi, C | Activation from injured reserve | Jul 12 | 16:23 |
| Tom | Ortiz, Pit, P | for | Jones, Pit, P → IR | DL | Jul 12 | 10:09 |
| Tom | Ramos, SF, OF | for | Bellinger, Chi, OF → IR | DL | Jul 12 | 10:06 |
| Ben | Mikolas, StL, P | for | Hicks, SF, P | Free Replacement | Jul 12 | 09:35 |
| James | Harper, Phi, 1B | for | Clemens, Phi, 1B | Activation from injured reserve | Jul 10 | 15:26 |
| Tom | Bellinger, Chi, OF | for | Matos, SF, OF | Free Replacement | Jul 9 | 22:49 |
| John | Wood, Was, OF | for | Pederson, Ari, OF | Free Replacement | Jul 9 | 21:01 |
| John | Schwarber, Phi, OF | for | Wood, Was, OF | Activation from injured reserve | Jul 9 | 21:01 |
| John | Knack, LA, P | for | Falter, Pit, P → IR | DL | Jul 9 | 20:54 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Nootbaar, StL, OF | for | Bellinger, Chi, OF | Activation from injured reserve | Jul 9 | 10:09 |
| Tom | , | for | Mitchell, Mil, IR | Released from injured reserve | Jul 5 | 00:32 |
| John | Wood, Was, OF | for | Schwarber, Phi, OF → IR | DL | Jul 2 | 18:00 |
| Tom | Scott, NY, P | for | Megill, NY, P | Minors | Jul 2 | 15:40 |
| Tom | Chapman, Pit, P | for | Meyer, Mia, P | Free Replacement | Jul 2 | 06:47 |
| John | Diaz, Col, C | for | Stallings, Col, C | Activation from injured reserve | Jul 1 | 19:00 |
| Ben | Rojas, LA, SS | for | Arcia, Atl, SS | Free Replacement | Jul 1 | 11:57 |
| John | Gibson, StL, P | for | Winn, SF, P → IR | DL | Jun 30 | 13:34 |
| John | Taillon, Chi, P | for | Assad, Chi, P → IR | DL | Jun 30 | 13:33 |
| James | Clemens, Phi, 1B | for | Tellez, Pit, 1B | Free Replacement | Jun 29 | 20:07 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Gonzales, Pit, DH | for | Perkins, Mil, DH | Free Replacement | Jun 29 | 20:01 |
| James | Rodgers, Col, 2B | for | Gonzales, Pit, 2B | Activation from injured reserve | Jun 29 | 20:01 |
| James | Tellez, Pit, 1B | for | Harper, Phi, 1B → IR | DL | Jun 29 | 17:55 |
| John | Myers, Mil, P | for | Garrett, Mia, P → IR | DL | Jun 28 | 08:06 |
| Tom | , | for | Encarnacion-Strand, Cin, IR | Released from injured reserve | Jun 27 | 09:55 |
| Tom | Matos, SF, OF | for | Tatis Jr., SD, OF → IR | DL | Jun 26 | 08:35 |
| Tom | Sanchez, Mia, OF | for | Friedl, Cin, OF → IR | DL | Jun 24 | 17:08 |
| Ben | Contreras, StL, C | for | Herrera, StL, C | Activation from injured reserve | Jun 24 | 09:22 |
| John | Waldron, SD, P | for | Luzardo, Mia, P → IR | DL | Jun 23 | 11:29 |
| James | Chourio, Mil, OF | for | Tauchman, Chi, OF → IR | DL | Jun 20 | 20:17 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Miller, LA, P | for | Gasser, Mil, P | Activation from injured reserve | Jun 19 | 23:04 |
| James | Rea, Mil, P | for | Buehler, LA, P → IR | DL | Jun 19 | 20:27 |
| Toby | Kelenic, Atl, OF | for | Jones, Col, OF | Free Replacement | Jun 18 | 10:29 |
| Toby | Vesia, LA, P | for | Nardi, Mia, P | Free Replacement | Jun 18 | 10:25 |
| John | Pederson, Ari, OF | for | Betts, LA, OF → IR | DL | Jun 17 | 19:23 |
| Tom | Soler, SF, OF | for | Harris II, Atl, OF → IR | DL | Jun 17 | 17:57 |
| John | Turner, Phi, SS | for | Sosa, Phi, SS | Activation from injured reserve | Jun 16 | 14:31 |
| John | Stallings, Col, C | for | Diaz, Col, C → IR | DL | Jun 16 | 14:27 |
| Ben | Marsh, Phi, OF | for | Rojas, Phi, OF | Activation from injured reserve | Jun 15 | 13:14 |
| John | Winn, SF, P | for | Gomber, Col, P | Activation from injured reserve | Jun 14 | 10:57 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Meyer, Mia, P | for | Brown, Chi, P → IR | DL | Jun 14 | 06:39 |
| John | Falter, Pit, P | for | Weathers, Mia, P → IR | DL | Jun 9 | 15:44 |
| James | Gonzales, Pit, 2B | for | Rodgers, Col, 2B → IR | DL | Jun 9 | 10:35 |
| James | Perkins, Mil, DH | for | Gonzales, Pit, DH | Free Replacement | Jun 9 | 10:34 |
| James | Sanchez, Mil, C | for | Gomes, Chi, C | Free Replacement | Jun 8 | 10:11 |
| James | Merrill, SD, OF | for | Dahl, SD, OF | Free Replacement | Jun 7 | 15:07 |
| James | Gonzales, Pit, DH | for | Merrill, SD, DH | Free Replacement | Jun 7 | 15:07 |
| John | Weathers, Mia, P | for | Williams, Was, P → IR | DL | Jun 6 | 21:32 |
| Ben | Sanchez, Phi, P | for | Montgomery, Ari, P | Free Replacement | Jun 6 | 12:57 |
| Tom | Candelario, Cin, 3B | for | Encarnacion-Strand, Cin, 1B → IR | DL | Jun 5 | 16:24 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Dahl, SD, OF | for | Perkins, Mil, OF | Free Replacement | Jun 4 | 19:52 |
| Ben | Bader, NY, OF | for | Marsh, Phi, OF → IR | DL | Jun 4 | 09:03 |
| Ben | Irvin, Was, P | for | Quintana, NY, P | Free Replacement | Jun 3 | 09:06 |
| Tom | Megill, NY, P | for | Darvish, SD, P → IR | DL | Jun 1 | 16:28 |
| Tom | Bailey, SF, C | for | Grandal, Pit, C | Free Replacement | Jun 1 | 16:12 |
| Tom | Friedl, Cin, OF | for | Bader, NY, OF | Free Replacement | Jun 1 | 16:08 |
| Tom | Neris, Chi, P | for | Musgrove, SD, P → IR | DL | Jun 1 | 15:49 |
| Ben | Busch, Chi, 3B | for | Candelario, Cin, 3B | Free Replacement | Jun 1 | 08:34 |
| Ben | Hoskins, Mil, 1B | for | Busch, Chi, 1B | Activation from injured reserve | Jun 1 | 08:33 |
| Ben | Rojas, Phi, OF | for | Nootbaar, StL, OF → IR | DL | May 31 | 14:05 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Montero, Col, 1B | for | Wade Jr., SF, 1B → IR | DL | May 31 | 10:41 |
| James | McCutchen, Pit, OF | for | Kelenic, Atl, OF | Free Replacement | May 30 | 15:45 |
| James | Perkins, Mil, OF | for | Chourio, Mil, OF | Free Replacement | May 30 | 15:43 |
| Ben | Busch, Chi, 1B | for | Bauers, Mil, 1B | Free Replacement | May 30 | 11:16 |
| Ben | Burleson, StL, OF | for | Soler, SF, OF | Free Replacement | May 30 | 11:12 |
| John | Murphy, Atl, C | for | Bailey, SF, C | Activation from injured reserve | May 28 | 21:28 |
| John | Thomas, Was, OF | for | Perkins, Mil, OF | Activation from injured reserve | May 28 | 21:24 |
| James | Gasser, Mil, P | for | Neris, Chi, P | Free Replacement | May 27 | 19:16 |
| Tom | Brown, Chi, P | for | Hudson, LA, P | Free Replacement | May 27 | 17:57 |
| Levent | Benson, Cin, OF | for | Rojas, Phi, OF | Free Replacement | May 27 | 06:45 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Newman, Cin, 3B | for | Busch, Chi, 3B | Free Replacement | May 27 | 06:44 |
| James | Kelenic, Atl, OF | for | Acuna Jr., Atl, OF → IR | DL | May 26 | 19:48 |
| John | Gomber, Col, P | for | Winn, SF, P → IR | DL | May 25 | 06:42 |
| John | Sosa, Phi, SS | for | Rojas, LA, SS | Free Replacement | May 25 | 06:32 |
| James | Phillips, LA, P | for | Butto, NY, P | Activation from injured reserve | May 24 | 23:00 |
| Tom | Musgrove, SD, P | for | Taillon, Chi, P | Activation from injured reserve | May 23 | 16:25 |
| James | , | for | Bryant, Col, IR | Released from injured reserve | May 23 | 09:54 |
| James | Vientos, NY, 3B | for | Baty, NY, 3B | Free Replacement | May 21 | 21:22 |
| Ben | Candelario, Cin, 3B | for | Lipscomb, Was, 3B | Minors | May 19 | 11:42 |
| Ben | Soler, SF, OF | for | Yastrzemski, SF, OF | Activation from injured reserve | May 17 | 22:08 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Bauers, Mil, 1B | for | Muncy, LA, 3B → IR | DL | May 17 | 21:58 |
| Ben | Lipscomb, Was, 3B | for | Hoskins, Mil, 1B → IR | DL | May 15 | 14:34 |
| John | Luzardo, Mia, P | for | Alzolay, Chi, P | Activation from injured reserve | May 13 | 10:20 |
| Ben | Yastrzemski, SF, OF | for | Conforto, SF, OF | DL | May 13 | 09:53 |
| Ben | Megill, Mil, P | for | Payamps, Mil, P | Free Replacement | May 10 | 14:11 |
| John | , | for | Puk, Mia, IR | Released from injured reserve | May 10 | 09:54 |
| John | Assad, Chi, P | for | Irvin, Was, P | Free Replacement | May 10 | 09:53 |
| John | Garrett, Mia, P | for | Assad, Chi, P | Activation from injured reserve | May 10 | 09:53 |
| John | Rojas, LA, SS | for | Turner, Phi, SS → IR | DL | May 10 | 09:49 |
| John | Williams, Was, P | for | Perez, Pit, P | Free Replacement | May 10 | 09:47 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Sewald, Ari, P | for | Williams, Was, P | Activation from injured reserve | May 10 | 09:46 |
| John | , | for | Montas, Cin, IR | Released from injured reserve | May 10 | 09:45 |
| Ben | Conforto, SF, OF | for | Soler, SF, OF → IR | DL | May 9 | 11:55 |
| James | Stone, LA, P | for | Kelly, LA, P | DL | May 8 | 18:13 |
| James | Skenes, Pit, P | for | Rea, Mil, P | Free Replacement | May 8 | 18:07 |
| Ben | Herrera, StL, C | for | Contreras, StL, C → IR | DL | May 8 | 09:20 |
| Ben | Bellinger, Chi, OF | for | Conforto, SF, OF | Activation from injured reserve | May 7 | 20:22 |
| Tom | Grandal, Pit, C | for | Davis, Pit, C | Minors | May 6 | 18:57 |
| James | Kelly, LA, P | for | Phillips, LA, P → IR | DL | May 6 | 14:53 |
| James | Joe, Pit, OF | for | Outman, LA, OF | Free Replacement | May 6 | 14:26 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Hudson, LA, P | for | Musgrove, SD, P → IR | DL | May 6 | 07:43 |
| Ben | Steele, Chi, P | for | Matz, StL, P | Activation from injured reserve | May 5 | 22:05 |
| James | Buehler, LA, P | for | Falter, Pit, P | Activation from injured reserve | May 3 | 09:51 |
| Tom | Darvish, SD, P | for | Rogers, Mia, P | Activation from injured reserve | May 1 | 09:40 |
| James | Amaya, Chi, C | for | Alvarez, NY, C → IR | DL | Apr 29 | 17:53 |
| James | Neris, Chi, P | for | Cabrera, Mia, P | Free Replacement | Apr 29 | 17:52 |
| John | Alzolay, Chi, P | for | Luzardo, Mia, P → IR | DL | Apr 27 | 13:06 |
| Levent | Rojas, Phi, OF | for | Joe, Pit, OF | Free Replacement | Apr 27 | 03:42 |
| Levent | Parker, Was, P | for | Snell, SD, P → IR | DL | Apr 27 | 03:25 |
| John | Perkins, Mil, OF | for | Thomas, Was, OF → IR | DL | Apr 25 | 19:21 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Tauchman, Chi, OF | for | Walker, StL, OF | Minors | Apr 25 | 11:19 |
| Ben | Conforto, SF, OF | for | Bellinger, Chi, OF → IR | DL | Apr 24 | 21:19 |
| Ben | Arcia, Atl, SS | for | Edman, StL, SS → IR | DL | Apr 24 | 21:18 |
| Ben | Gore, Was, P | for | Senga, NY, P → IR | DL | Apr 24 | 21:18 |
| James | Falter, Pit, P | for | Buehler, LA, P → IR | DL | Apr 24 | 14:42 |
| James | Baty, NY, 3B | for | Bryant, Col, 1B → IR | DL | Apr 24 | 14:05 |
| John | Williams, Was, P | for | Montas, Cin, P → IR | DL | Apr 23 | 22:01 |
| Ben | Payamps, Mil, P | for | Alzolay, Chi, P | Free Replacement | Apr 22 | 20:01 |
| Tom | Bader, NY, OF | for | Conforto, SF, OF | Free Replacement | Apr 22 | 04:30 |
| Tom | Taillon, Chi, P | for | Darvish, SD, P → IR | DL | Apr 22 | 04:28 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Pages, LA, OF | for | Kelenic, Atl, OF | Free Replacement | Apr 21 | 21:35 |
| James | Rea, Mil, P | for | Stone, LA, P | Free Replacement | Apr 21 | 11:41 |
| John | Winker, Was, DH | for | Wade, SD, DH | Free Replacement | Apr 20 | 14:11 |
| John | Irvin, Was, P | for | Puk, Mia, P → IR | DL | Apr 20 | 14:08 |
| Ben | Montgomery, Ari, P | for | Gallegos, StL, P | Free Replacement | Apr 20 | 12:45 |
| James | Cabrera, Mia, P | for | Meyer, Mia, P | Minors | Apr 16 | 22:58 |
| Levent | Joe, Pit, OF | for | Pederson, Ari, OF | Free Replacement | Apr 16 | 09:41 |
| Levent | Busch, Chi, 3B | for | Candelario, Cin, 3B | Free Replacement | Apr 16 | 09:39 |
| James | Stone, LA, P | for | Miller, LA, P → IR | DL | Apr 15 | 11:10 |
| James | Butto, NY, P | for | Neris, Chi, P | Free Replacement | Apr 14 | 19:31 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Meyer, Mia, P | for | Lamet, LA, P | Free Replacement | Apr 14 | 11:27 |
| Levent | Turnbull, Phi, P | for | Strider, Atl, P → IR | DL | Apr 14 | 02:56 |
| John | Perez, Pit, P | for | Kinley, Col, P | Free Replacement | Apr 13 | 12:41 |
| Ben | Matz, StL, P | for | Hendricks, Chi, P | Free Replacement | Apr 6 | 10:46 |
| John | Montas, Cin, P | for | Sewald, Ari, P → IR | DL | Apr 5 | 20:58 |
| Tom | Conforto, SF, OF | for | Mitchell, Mil, OF → IR | DL | Apr 5 | 03:35 |
| Tom | Turang, Mil, 2B | for | Merrifield, Phi, 2B | Free Replacement | Apr 5 | 01:12 |
| James | Lamet, LA, P | for | Stone, LA, P | Free Replacement | Apr 4 | 10:36 |
| John | Assad, Chi, P | for | Garrett, Mia, P → IR | DL | Apr 3 | 19:24 |
| John | Bailey, SF, C | for | Murphy, Atl, C → IR | DL | Apr 3 | 18:50 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Donovan, StL, DH | for | Suwinski, Pit, DH | Free Replacement | Apr 3 | 14:39 |
| Ben | Hicks, SF, P | for | Steele, Chi, P → IR | DL | Apr 1 | 10:48 |