| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Donovan, StL, 2B | for | Marte, Ari, 2B | DL | Oct 3 | 11:13 |
| Ben | , | for | O'Neill, StL, IR | Released from injured reserve | Oct 3 | 11:13 |
| Ben | Thompson, StL, P | for | Clevinger, SD, P | Free Replacement | Sep 26 | 10:21 |
| John | Farmer, Cin, SS | for | Peterson, Mil, 2B | Free Replacement | Sep 25 | 09:56 |
| John | Daza, Col, OF | for | Farmer, Cin, SS | Free Replacement | Sep 25 | 09:53 |
| Tom | Ortiz, Pit, P | for | Strider, Atl, P → IR | DL | Sep 24 | 17:16 |
| Tom | De La Cruz, Mia, DH | for | Rojas, Ari, OF | Free Replacement | Sep 24 | 09:12 |
| Tom | Rojas, Ari, OF | for | De La Cruz, Mia, OF | Free Replacement | Sep 24 | 09:12 |
| Tom | De La Cruz, Mia, OF | for | Rojas, Ari, DH | Free Replacement | Sep 24 | 09:10 |
| Tom | Garrett, Mia, P | for | Rogers, Mia, P → IR | DL | Sep 23 | 07:31 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | India, Cin, 2B | for | Albies, Atl, 2B → IR | DL | Sep 20 | 20:25 |
| Ben | Dickerson, StL, OF | for | O'Neill, StL, OF → IR | DL | Sep 20 | 15:50 |
| Tom | Lodolo, Cin, P | for | Robertson, Chi, P | Free Replacement | Sep 20 | 10:13 |
| Ben | Berti, Mia, 2B | for | India, Cin, 2B | Free Replacement | Sep 19 | 22:21 |
| Ben | Scherzer, NY, P | for | Cabrera, Mia, P | Activation from injured reserve | Sep 19 | 22:18 |
| Ben | , | for | Matz, StL, IR | Released from injured reserve | Sep 19 | 22:17 |
| Ben | , | for | Wood, SF, IR | Released from injured reserve | Sep 19 | 22:16 |
| Tom | Aquino, Cin, OF | for | Fraley, Cin, OF | Free Replacement | Sep 19 | 08:24 |
| Tom | Rogers, Mia, P | for | Finnegan, Was, P | Free Replacement | Sep 16 | 23:57 |
| Tom | Castro, Pit, 2B | for | Berti, Mia, 2B | Free Replacement | Sep 16 | 23:33 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Albies, Atl, 2B | for | Grissom, Atl, 2B | Activation from injured reserve | Sep 16 | 23:29 |
| Ben | , | for | Eflin, Phi, IR | Released from injured reserve | Sep 14 | 10:15 |
| Tom | McCarthy, Ari, OF | for | Marte, NY, OF → IR | DL | Sep 12 | 08:18 |
| Ben | Cabrera, Mia, P | for | Scherzer, NY, P → IR | DL | Sep 9 | 11:45 |
| Onder | Houser, Mil, P | for | Minter, Atl, P | Activation from injured reserve | Sep 8 | 08:29 |
| Onder | Treinen, LA, P | for | Steele, Chi, P | Free Replacement | Sep 8 | 08:28 |
| Onder | , | for | Treinen, LA, IR | Released from injured reserve | Sep 8 | 08:27 |
| Tom | Alfaro, SD, C | for | Fortes, Mia, C | Activation from injured reserve | Sep 7 | 11:53 |
| John | Peterson, Mil, 2B | for | Thomas, Ari, OF | Activation from injured reserve | Sep 6 | 20:31 |
| John | , | for | Suwinski, Pit, IR | Released from injured reserve | Sep 6 | 20:28 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | , | for | Hernandez, Was, IR | Released from injured reserve | Sep 6 | 20:27 |
| John | Carrasco, NY, P | for | Cobb, SF, P | Activation from injured reserve | Sep 6 | 20:27 |
| Ben | Flaherty, StL, P | for | Wood, SF, P → IR | DL | Sep 3 | 15:24 |
| Ben | , | for | Flaherty, StL, IR | Released from injured reserve | Sep 3 | 15:24 |
| Ben | Nootbaar, StL, OF | for | Carlson, StL, OF | Free Replacement | Sep 2 | 11:12 |
| Tom | Carroll, Ari, OF | for | Grossman, Atl, OF | Free Replacement | Sep 2 | 00:48 |
| Tom | Hiura, Mil, 1B | for | Meneses, Was, 1B | Free Replacement | Sep 1 | 00:03 |
| Onder | , | for | Hendricks, Chi, IR | Released from injured reserve | Aug 27 | 11:55 |
| Tom | Fortes, Mia, C | for | Alfaro, SD, C → IR | DL | Aug 26 | 22:25 |
| Tom | Harper, Phi, OF | for | Senzel, Cin, OF | Activation from injured reserve | Aug 25 | 23:08 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | , | for | Yepez, StL, IR | Released from injured reserve | Aug 25 | 09:31 |
| Onder | Narvaez, Mil, C | for | Higgins, Chi, C | Activation from injured reserve | Aug 23 | 07:48 |
| Ben | Diaz, Cin, P | for | Wick, Chi, P | Free Replacement | Aug 22 | 11:44 |
| Tom | Fraley, Cin, OF | for | McCarthy, Ari, OF | Free Replacement | Aug 21 | 16:21 |
| John | Thomas, Was, OF | for | Hernandez, Was, OF → IR | DL | Aug 21 | 14:37 |
| John | Cobb, SF, P | for | Carrasco, NY, P → IR | DL | Aug 21 | 08:22 |
| Ben | Taylor, LA, OF | for | Taylor, Mil, OF | Free Replacement | Aug 20 | 14:19 |
| Ben | Pujols, StL, DH | for | Taylor, LA, DH | Free Replacement | Aug 20 | 14:18 |
| Tom | Grossman, Atl, OF | for | Morel, Chi, OF | Free Replacement | Aug 18 | 21:28 |
| Tom | Meneses, Was, 1B | for | Votto, Cin, 1B | Free Replacement | Aug 17 | 22:49 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | , | for | Rios, LA, IR | Released from injured reserve | Aug 14 | 17:22 |
| Tom | Grissom, Atl, 2B | for | Gorman, StL, 2B | Free Replacement | Aug 13 | 23:46 |
| Onder | Steele, Chi, P | for | Brubaker, Pit, P | Free Replacement | Aug 13 | 15:01 |
| Onder | Kim, SD, DH | for | Beer, Ari, DH | Free Replacement | Aug 13 | 14:58 |
| Onder | Higgins, Chi, C | for | Narvaez, Mil, C → IR | DL | Aug 13 | 14:53 |
| Tom | Berti, Mia, 2B | for | Garcia, Was, 2B | Activation from injured reserve | Aug 12 | 22:59 |
| Ben | Montgomery, StL, P | for | Pallante, StL, P | Free Replacement | Aug 8 | 10:27 |
| John | Junis, SF, P | for | Peterson, NY, P | Activation from injured reserve | Aug 6 | 22:47 |
| John | , | for | Duvall, Atl, IR | Released from injured reserve | Aug 6 | 22:43 |
| John | Thomas, Ari, OF | for | Peterson, Mil, OF → IR | DL | Aug 6 | 22:42 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Reynolds, Pit, OF | for | Thomas, Ari, OF | Activation from injured reserve | Aug 6 | 22:41 |
| Ben | Cruz, Pit, SS | for | Donovan, StL, SS | Free Replacement | Aug 6 | 10:04 |
| Ben | Taylor, LA, DH | for | Cruz, Pit, DH | Activation from injured reserve | Aug 6 | 10:04 |
| James | Tatis Jr., SD, OF | for | Garcia, Mia, OF | Activation from injured reserve | Aug 5 | 23:33 |
| Tom | McCarthy, Ari, OF | for | Pham, Cin, OF | Free Replacement | Aug 4 | 14:29 |
| Onder | Myers, SD, OF | for | Robles, Was, OF | Activation from injured reserve | Aug 4 | 00:27 |
| Onder | deGrom, NY, P | for | Kuhl, Col, P | Activation from injured reserve | Aug 4 | 00:26 |
| Ben | , | for | Bader, StL, IR | Released from injured reserve | Aug 3 | 11:33 |
| Ben | Wick, Chi, P | for | Rogers, SD, P | Free Replacement | Aug 3 | 11:31 |
| Tom | Rojas, Ari, DH | for | Ruiz, SD, DH | Free Replacement | Aug 2 | 20:16 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Dominguez, Phi, P | for | Gore, SD, P → IR | DL | Jul 31 | 16:44 |
| Onder | Robles, Was, OF | for | Myers, SD, OF → IR | DL | Jul 29 | 07:46 |
| Onder | Kuhl, Col, P | for | deGrom, NY, P → IR | DL | Jul 29 | 07:44 |
| Onder | Minter, Atl, P | for | Houser, Mil, P → IR | DL | Jul 29 | 07:40 |
| Onder | Keller, Pit, P | for | Hendricks, Chi, P → IR | DL | Jul 29 | 07:35 |
| Onder | Brubaker, Pit, P | for | Treinen, LA, P → IR | DL | Jul 29 | 07:32 |
| Ben | Taylor, Mil, OF | for | Yepez, StL, OF → IR | DL | Jul 27 | 10:49 |
| Ben | Pallante, StL, P | for | Matz, StL, P → IR | DL | Jul 25 | 23:24 |
| James | Luzardo, Mia, P | for | Lamet, SD, P | Activation from injured reserve | Jul 24 | 20:30 |
| John | Peterson, Mil, OF | for | Duvall, Atl, OF → IR | DL | Jul 24 | 17:30 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| John | Drury, Cin, DH | for | Kim, SD, DH | Free Replacement | Jul 18 | 20:07 |
| John | Duvall, Atl, OF | for | Suwinski, Pit, OF → IR | Minors | Jul 18 | 19:57 |
| Ben | Wood, SF, P | for | Pallante, StL, P | Free Replacement | Jul 18 | 10:30 |
| Tom | Ruiz, SD, DH | for | Berti, Mia, 2B → IR | DL | Jul 17 | 09:42 |
| Tom | Berti, Mia, 2B | for | Ruiz, SD, OF | Activation from injured reserve | Jul 17 | 09:40 |
| Tom | Ruiz, SD, OF | for | Berti, Mia, DH → IR | DL | Jul 17 | 09:39 |
| Tom | Suarez, Phi, P | for | Dominguez, Phi, P | Activation from injured reserve | Jul 16 | 07:14 |
| Ben | Matz, StL, P | for | Hicks, StL, P | Activation from injured reserve | Jul 15 | 10:05 |
| John | Thomas, Ari, OF | for | Reynolds, Pit, OF → IR | DL | Jul 14 | 19:20 |
| Tom | Finnegan, Was, P | for | Rainey, Was, P | Free Replacement | Jul 14 | 18:36 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Lamet, SD, P | for | Greene, Cin, P | Free Replacement | Jul 10 | 10:44 |
| Tom | , | for | Sims, Cin, IR | Released from injured reserve | Jul 10 | 10:44 |
| Tom | Dominguez, Phi, P | for | Suarez, Phi, P → IR | DL | Jul 9 | 08:02 |
| Ben | Harris, Atl, OF | for | Taylor, LA, OF → IR | DL | Jul 7 | 15:54 |
| Ben | O'Neill, StL, OF | for | Cain, Mil, OF | Activation from injured reserve | Jul 6 | 09:16 |
| Ben | Cain, Mil, OF | for | Bader, StL, OF → IR | DL | Jul 6 | 09:15 |
| Tom | Senzel, Cin, OF | for | Thomas, Ari, OF | Free Replacement | Jul 6 | 08:41 |
| Levent | Perez, Pit, C | for | Casali, SF, C | Free Replacement | Jul 5 | 13:56 |
| Levent | Longoria, SF, 3B | for | Moran, Cin, 1B | Minors | Jul 5 | 13:52 |
| James | Caratini, Mil, C | for | McCann, NY, C | Free Replacement | Jul 4 | 22:10 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | White, LA, P | for | Luzardo, Mia, P → IR | DL | Jul 4 | 16:52 |
| Ben | Hicks, StL, P | for | Megill, NY, P | Activation from injured reserve | Jul 4 | 11:22 |
| Ben | Megill, NY, P | for | Eflin, Phi, P → IR | DL | Jul 4 | 11:21 |
| James | McCann, NY, C | for | Caratini, Mil, C | Activation from injured reserve | Jul 3 | 15:07 |
| John | Suwinski, Pit, OF | for | Daza, Col, OF | Free Replacement | Jul 3 | 10:20 |
| John | Walker, NY, P | for | Wood, SF, P | Free Replacement | Jul 2 | 21:17 |
| Tom | Morel, Chi, OF | for | Harper, Phi, OF → IR | DL | Jul 2 | 6:33 |
| Ben | Pallante, StL, P | for | Flaherty, StL, P → IR | DL | Jul 1 | 09:37 |
| Ben | Scherzer, NY, P | for | Pallante, StL, P | Activation from injured reserve | Jul 1 | 09:37 |
| John | Peterson, NY, P | for | Junis, SF, P → IR | DL | Jun 29 | 21:33 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | , | for | Molina, StL, IR | Released from injured reserve | Jun 28 | 12:47 |
| Tom | Hoerner, Chi, SS | for | Gregorius, Phi, SS | Free Replacement | Jun 28 | 12:46 |
| Ben | Yepez, StL, OF | for | O'Neill, StL, OF → IR | DL | Jun 21 | 10:39 |
| Ben | Cruz, Pit, DH | for | Yepez, StL, DH | Free Replacement | Jun 21 | 10:38 |
| Tom | Alfaro, SD, C | for | Molina, StL, C → IR | DL | Jun 17 | 13:44 |
| James | Greene, Cin, P | for | Rogers, Mia, P | Free Replacement | Jun 15 | 20:02 |
| Tom | Berti, Mia, DH | for | Longoria, SF, DH | Free Replacement | Jun 15 | 01:53 |
| Tom | Garcia, Was, 2B | for | Albies, Atl, 2B → IR | DL | Jun 15 | 01:51 |
| Ladd | Hudson, StL, P | for | DeSclafani, SF, P | DL | Jun 14 | 15:28 |
| Ben | Flaherty, StL, P | for | Floro, Mia, P | Free Replacement | Jun 14 | 15:23 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | India, Cin, 2B | for | Urias, Mil, SS | Activation from injured reserve | Jun 14 | 05:24 |
| James | Scott, Mia, P | for | Buehler, LA, P → IR | DL | Jun 12 | 21:20 |
| James | Chavis, Pit, DH | for | Rios, LA, DH → IR | DL | Jun 12 | 21:16 |
| Ben | Pallante, StL, P | for | Hicks, StL, P → IR | DL | Jun 11 | 09:52 |
| Tom | , | for | Megill, NY, IR | Released from injured reserve | Jun 11 | 02:16 |
| Ben | Contreras, Pit, P | for | Matz, StL, P → IR | DL | Jun 10 | 10:39 |
| John | Farmer, Cin, SS | for | Hoerner, Chi, SS | Free Replacement | Jun 9 | 16:40 |
| Levent | Slater, SF, OF | for | Aquino, Cin, OF | Activation from injured reserve | Jun 6 | 11:07 |
| Levent | Renfroe, Mil, OF | for | Taylor, Mil, OF | Activation from injured reserve | Jun 6 | 11:07 |
| Tom | Gregorius, Phi, SS | for | Villar, Chi, SS | Activation from injured reserve | Jun 6 | 08:10 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Contreras, Atl, C | for | Knizner, StL, C | Free Replacement | Jun 5 | 11:05 |
| John | Junis, SF, P | for | Cobb, SF, P | Free Replacement | Jun 4 | 11:40 |
| John | , | for | Heyward, Chi, IR | Released from injured reserve | Jun 4 | 09:36 |
| James | Kershaw, LA, P | for | Warren, Cin, P | Activation from injured reserve | Jun 2 | 21:58 |
| Tom | Thomas, Ari, OF | for | Duvall, Atl, OF | Free Replacement | May 30 | 08:29 |
| Tom | Longoria, SF, DH | for | Thomas, Ari, DH | Free Replacement | May 30 | 08:28 |
| James | Warren, Cin, P | for | Wick, Chi, P | Free Replacement | May 29 | 16:40 |
| Tom | Helsley, StL, P | for | Kennedy, Ari, P | Free Replacement | May 27 | 23:41 |
| Tom | Gorman, StL, 2B | for | Farmer, Cin, SS | Free Replacement | May 25 | 23:22 |
| Levent | Taylor, Mil, OF | for | Renfroe, Mil, OF → IR | DL | May 24 | 13:31 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Levent | Aquino, Cin, OF | for | Slater, SF, OF → IR | DL | May 24 | 13:30 |
| Levent | Snell, SD, P | for | Kuhl, Col, P | Activation from injured reserve | May 24 | 13:26 |
| Levent | Pederson, SF, OF | for | Drury, Cin, OF | DL | May 20 | 11:15 |
| Ben | Eflin, Phi, P | for | Scherzer, NY, P → IR | DL | May 20 | 08:19 |
| Ben | Stroman, Chi, P | for | Eflin, Phi, P | Activation from injured reserve | May 20 | 08:19 |
| Levent | Drury, Cin, OF | for | Pederson, SF, OF → IR | DL | May 18 | 11:15 |
| Tom | Robertson, Chi, P | for | Junis, SF, P | Activation from injured reserve | May 19 | 00:22 |
| John | Daza, Col, OF | for | Heyward, Chi, OF → IR | DL | May 18 | 20:11 |
| Levent | Casali, SF, C | for | Bart, SF, C | Free Replacement | May 18 | 11:00 |
| Levent | Moran, Cin, 1B | for | Pujols, StL, 1B | Free Replacement | May 17 | 04:51 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Tom | Strider, Atl, P | for | Megill, NY, P → IR | DL | May 16 | 20:51 |
| James | Rios, LA, DH | for | Chavis, Pit, DH | Free Replacement | May 16 | 16:58 |
| Ben | Eflin, Phi, P | for | Bender, Mia, P | Activation from injured reserve | May 16 | 13:17 |
| Tom | Wainwright, StL, P | for | Martinez, SD, P | Activation from injured reserve | May 15 | 10:08 |
| James | Wick, Chi, P | for | Kershaw, LA, P → IR | DL | May 15 | 10:06 |
| James | Caratini, Mil, C | for | McCann, NY, C → IR | DL | May 15 | 10:03 |
| Ben | Donovan, StL, SS | for | Berti, Mia, 2B | DL | May 14 | 17:54 |
| Tom | Thomas, Ari, DH | for | Smith, NY, DH | Free Replacement | May 12 | 21:16 |
| Tom | Kennedy, Ari, P | for | Sims, Cin, P → IR | DL | May 12 | 15:24 |
| John | Anderson, LA, P | for | Stratton, Pit, P | Free Replacement | May 12 | 07:15 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| Ben | Urias, Mil, SS | for | DeJong, StL, SS | Minors | May 11 | 09:30 |
| Ben | Yepez, StL, DH | for | Urias, Mil, DH | Free Replacement | May 11 | 09:29 |
| Tom | Farmer, Cin, SS | for | Gregorius, Phi, SS → IR | DL | May 11 | 00:07 |
| Tom | Junis, SF, P | for | Robertson, Chi, P → IR | DL | May 10 | 23:54 |
| Tom | Martinez, SD, P | for | Wainwright, StL, P → IR | DL | May 10 | 23:53 |
| Ben | Quintana, Pit, P | for | Stroman, Chi, P → IR | DL | May 10 | 09:48 |
| Ben | Bender, Mia, P | for | Eflin, Phi, P → IR | DL | May 8 | 11:10 |
| Ben | Floro, Mia, P | for | Bender, Mia, P | Free Replacement | May 8 | 10:55 |
| Levent | Melancon, Ari, P | for | Kennedy, Ari, P | Activation from injured reserve | May 7 | 14:53 |
| Levent | Thompson, Chi, P | for | Marquez, Col, P | Free Replacement | May 6 | 15:51 |
| Owner | New Player | | Old Player | Reason | Date | EDT |
| James | Iglesias, Col, SS | for | Tatis Jr., SD, SS → IR | DL | May 5 | 09:16 |
| Toby | Ruf, SF, OF | for | Naquin, Cin, OF → IR | DL | May 4 | 08:07 |
| Levent | Kennedy, Ari, P | for | Melancon, Ari, P → IR | DL | April 30 | 08:41 |
| Ben | Berti, Mia, 2B | for | India, Cin, 2B → IR | DL | Apr 29 | 15:05 |
| Toby | Reynolds, Cin, 3B | for | Bryant, Col, 3B → IR | DL | April 26 | 08:18 |
| Ben | India, Cin, 2B | for | Berti, Mia, 2B | Activation from injured reserve | Apr 25 | 15:01 |
| Toby | Herrera, Phi, OF | for | Rosario, Atl, OF → IR | DL | Apr 25 | 08:01 |
| Levent | Kuhl, Col, P | for | Snell, SD, P → IR | DL | April 15 | 08:42 |
| Ben | Berti, Mia, 2B | for | India, Cin, 2B → IR | DL | Apr 14 | 14:50 |